milk thistle depression

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. N-Acetylcysteine Please enable it to take advantage of the complete set of features! This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Marys milk falling onto its leaves. Bookshelf Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167, Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. By lowering LDL "bad" cholesterol levels, milk thistle may lower the chance of developing heart disease. 2023 May;475(5):621-635. doi: 10.1007/s00424-023-02795-y. https://www.wolterskluwercdi.com/facts-comparisons-online/. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. There is also concern that milk thistle might affect estrogen levels. If you choose to use milk thistle, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. People may also find it painful and worry about its effects on their appearance. Milk thistle seems to have few side effects, even when taken for several years. The active ingredients in milk thistle are a group of plant compounds collectively known as silymarin (1). The benefits of milk thistle can be attributed to its anti-inflammatory and antioxidant effects. Learn. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Get the facts on milk thistle for the liver. Researchers believe that silymarin reduced the oxidative stress traditionally attributed with diabetes (7). Interactions. These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with Alzheimers disease (18, 19, 20). Using different formulations together increases the risk of an overdose. Milk thistle (Silybum marianum) is said to have certain health benefits, including liver health, diabetes management, cancer treatment, and more. 2 skintightspandex 3 yr. ago Ya idk I've taken milk thistle for liver health and I have anxiety independent of it Nootropicsfan 3 yr. ago doi:10.1002/14651858.CD003620.pub3, Gillessen A, Schmidt HH. Summary In animals, milk thistle has been shown to stimulate bone mineralization. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Since milk thistle may lower blood sugar, people with diabetes should check with their doctor before taking the herb as it may make their blood sugar fall too low. Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-B) pathway. This publication is not copyrighted and is in the public domain. Milk thistle. It is primarily considered a cleansing agent and used to block or flush toxins from the body. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Botanicals and their bioactive phytochemicals for women's health, Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review, Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. eCollection 2023. Natural Medicines. After using 2 tablets a day and 1 month, indigestion and pain in my liver disappeared. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: A randomized, triple-blind, placebo-controlled clinical trial, By Soraiya Ebrahimpour Koujan, Bahram Pourghassem, Gargari Majid, Published February 15, 2015, Retrieved May 5, 2019, 8. https://www.ncbi.nlm.nih.gov/pubmed/28025940, Current Drug Targets, A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin, By Devi KP, Malar , Braidy , Nabavi , Nabavi, Published 2017, Retrieved May 5, 2019, 9. https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1964, Toxnet, Valerian Root, Reviewed by SRP on 9/9/2014, Retrieved May 5, 2019, 10. https://nccih.nih.gov/research/results/spotlight/040310.htm, National Center for Complementary and Integrative Health, Study Shows Chamomile Capsules Ease Anxiety Symptoms, Last Updated October 21, 2015, Retrieved May 5, 2019, 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440/, Evidence Based Complementary Medicine, Lavender and The Nervous System, Published March 14, 2013, By Peir Hossein Koulivand, Maryam Khaleghi Ghadiri, and Ali Gorji, Retrieved May 5, 2019, 12. https://www.webmd.com/vitamins/ai/ingredientmono-437/lemon-balm, WebMD.com, Lemon Balm, Retrieved May 5, 2019, Requirements for using and reposting articles. Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. However, many of these potential benefits are not backed by science. HHS Vulnerability Disclosure, Help You may opt-out of email communications at any time by clicking on National Library of Medicine The .gov means its official. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. The terms milk thistle and silymarin are often used interchangeably. Its main functions include antioxidant . However, there is a lack of . Milk thistle's main active component is silymarin which works by normalizing levels of both serotonin and dopamine. Do not use this product without medical advice if you are pregnant. Call your doctor for medical advice about side effects. We encourage you to discuss any decisions about treatment or care with your health care provider. Occasionally, people report various digestive side effects. Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. National Library of Medicine (US); 2022. Abdulghani A, Poghosyan M, Mehren A, Philipsen A, Anderzhanova E. Front Mol Neurosci. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Generic name: milk thistle [MILK-THIH-sull] The irony of this list of side effects being associated with drugs intended to treat anxiety, depression, and OCD is not lost on us, and ultimately begs the question, What naturally helps OCD?. Learn to concoct simple home remedies with easy-to-grow medicinal herbs, Some are looking to alternative medicines to help prevent or treat diseases like cancer. It is native to Mediterranean countries. 2016 Jul;41(7):1662-72. doi: 10.1007/s11064-016-1881-5. The benefits of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Closer to a Cancer Cure? . Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Its also unknown what doses would need to be prescribed for it to have a beneficial effect (18). This article looks at the evidence to, Whats the life expectancy of someone with cirrhosis of the liver? Now, one substance that we know can inhibit 5-alpha reductase, although it does it pretty weakly, is saw palmetto [200-500mg/Day, 2-3 . The following list is not exhaustive. Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. The research on milk thistle's use in cancer patients is promising, although more research is needed to determine its benefits. Eur Endocrinol. 2. Milk thistle may be a useful complementary therapy to help manage type 2 diabetes. #1: Milk thistle detoxifies the liver. A survey conducted in the U.S. reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Although rare, milk thistle may trigger a number of common and mild side effects. Some, but not all, milk thistle supplements are vegan. https://www.nccih.nih.gov/health/milk-thistle. What Are the Risks of Taking Milk Thistle? 2005 - 2023 WebMD LLC, an Internet Brands company. other information we have about you. If you or anyone you know is living with obsessive compulsive disorder (OCD), proclaiming the symptoms of this mood disorder as debilitating is a vast understatement. Medicinal use of this product has not been approved by the FDA. All rights reserved. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Nat Neurosci. Type 2 Diabetes According to research published in Phytomedicine in 2015, silymarin improved antioxidant capacity in the body and decreased inflammation in adults with type 2 diabetes by beating the placebo in a triple blind trial. Our study provides a new insight into the protective effects of silibinin in the treatment of anxiety/depression. Its not known whether milk thistle is helpful for other conditions. How Does Cirrhosis Affect Life Expectancy? . 2018;8:65-74. doi:10.2147/PTT.S169333. Well go over some of its most well-known benefits, Many people are interested in herbal supplements to support their liver health. Phytomedicine. doi:10.1097/CAD.0000000000000211, Fallah M, Davoodvandi A, Nikmanzar S, et al. They are seen in very high numbers in the brains of people with Alzheimers disease, meaning that milk thistle could potentially be used to help treat this difficult condition (21). Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks. Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating Itchiness Headache If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. Benefits. Milk thistle has been used for a range of psychiatric disorders including methamphetamine abuse and obsessive compulsive disorder. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Silybum marianum (milk thistle). Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). National Center for Complementary and Integrative Health. And Selenium too. Int J Mol Sci. Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity. Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. Side effects are always possible when taking supplements. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. People who have diabetes or endometriosis should check with a doctor before using milk thistle. Receive the latest, most useful health and wellness articles, tips, special discounts on nutritional supplements and so much more. One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). Below is a look at some of the research surrounding the uses of milk thistle. According to the International OCD Foundation about half of OCD patients stop taking their medications due to negative side effects. In fact, a recent review and analysis found that people routinely taking silymarin experienced a significant reduction in their fasting blood sugar levels and HbA1c, a measure of blood sugar control (44). Accessed Oct. 30, 2020. More research is needed before a standard dosage of milk thistle can be recommended, so check with your healthcare provider. Milk thistle is a popular herbal remedy that has been used for its therapeutic effects for centuries. Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action. Milk thistle is primarily taken in supplements sold as tablets, capsules, or extract primarily to help with liver function. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. 2023 Natural Wellness. Thats an alarmingly high percentage, leaving roughly 1.1 million people of the 2.2 million OCD sufferers in the United States seeking alternative treatment options (2) and natural remedies.
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